Talk to your healthcare provider and be sure that you thoroughly understand the laws in your state, as well as policies from your employer when it comes to consuming even low levels of THC. If does delta 8 thc you need to be drug-tested for work or other reasons, the THC present in full-spectrum CBD can show on a drug test. Remember that products advertised online aren’t always listed accurately.

• Alternative treatments for pain management, such as CBD oil for nerve pain, are being explored for many reasons.
• The second, using any other method to ingest CBD on a daily or twice-daily basis to ensure it stays in your bloodstream to do its work almost all the time.
• That’s not what the body needs … so the less work the intestines have to do, the better.
• Nociceptive pain can usually be treated with anti-inflammatory drugs such as Ibuprofen until the injury heals.
• The remaining content in this article will be concerned with peripheral neuropathy, although most of the principles outlined can apply to any of the above types.
• CBD gives your Endocannabinoid System the resources it needs to identify the dysfunction or imbalance that’s causing pain and helps bring it to balance.

CBD is a cannabinoid that does not contain any mind-altering compounds, instead being used solely for medicinal health purposes. This is unlike THC, which is the compound used to achieve a “high” and experience hallucinogenic effects. CBD actually has anti-inflammatory properties and has been known to help provide pain relief. When it comes to treating neuropathic pain, a higher dose is usually recommended — however, this can vary from person to person. Whenever using CBD for the first time, it’s wise to start low and increase slowly over time until you receive the benefits you’re looking for.

How To Find A Reputable CBD Vendor

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. One study found that only about one-third of CBD products sold online were labeled correctly and that more than 20% of the CBD products contained THC as well. Finally, CBD can have interactions with over-the-counter and prescription drugs. It’s important not to underestimate the risk of CBD, especially if you’re taking other medications or supplements. People who struggle to control their blood sugar levels due to the hormonal effects of stress and anxiety might be helped by CBD.

Pain from sciatica becomes difficult to treat since it is often a mix of two separate types of pain, nociceptive and neuropathic. Even if you are using a cream, it may interact with other medications. This is why it is important to discuss your use of CBD cream with a doctor. Preferably, you will want to find a doctor who recommends and uses a CBD topical cream themselves. They will have the best understanding because they have very likely done their homework on the issue.

CBD is generally considered safe for most people with little risk of side effects. People who try these softgels say the quality is obvious, 30 mg is the perfect can cbd oil help with bulging disc pre-bedtime dose, and they’re super easy to use. Keep in mind that CBD balms have a thicker consistency than ointments, lotions, creams, and sprays.

Another study used a survey that was handed out to 10 spinal cord injury patients at the Spinal Cord Injury ward of the Miami V.A. Hospital who were using marijuana to treat their symptoms. The survey was kept confidential and involved questions about the most common symptoms of the condition and how marijuana use affected them. One of the main benefits of using CBD products in the treatment of neuropathic pain is that it reduces the reliance on pain medication. This is especially important since the Centers for Disease Control and Prevention reports that, in the United States alone, approximately 130 people die every single day due to opioid overdose. Food and Drug Administration in 2006 so research could be conducted on Sativex to learn its effects on cancer pain. The said review of hundreds of studies looked at marijuana-based medicines on neuropathic pain in adults.

CBD oils for nerve pain can also treat inflammation from arthritis. Just like with shingles and shoulder pain, CBD oils reduce inflammation in the affected area which helps to relieve discomfort. Many studies have shown that using CBD oil for shingles nerve pain can help reduce inflammation and the risk of flare-ups. No, CBD oils won’t make you high since the THC level is 0.3% or below in most states. The “high” that you feel when using CBD oils for nerve pain comes from the oil’s ability to reduce inflammation and relax your body and mind. The benefits of using CBD oils for nerve pain are numerous, but it’s important to choose an oil that works well for you.

How Does Cbd Work To Combat Nerve Pain?

It is difficult to treat slipped discs because they don’t typically go back in place or heal well on their own once they become dislodged from their original position beneath the vertebrae. As a result, a slipped disc often leads to chronic, frustrating conditions that can include intense, day-to-day pain. Sciatica can also cause regular motion to feel much more difficult because the feet and legs feel weak.

First, it is unclear if cannabinoids can interact with the α3 GlyR, as the previous experiment was conducted with the α1 GlyR TM domains. There are 12 residues different within the four TM domains between the α1 and α3 subunits. Second, changes in chemical shift, although indicative of cannabinoid–receptor interaction, provide only limited information about direct binding at the site involving S296. To address these issues, we first converted the α1 subunit to the α3 subunit by mutating all 12 residues to match the α3 sequence. Using the high-resolution NMR structure of α1 GlyR TM domains solved in the lyso-1-palmitoylphosphotidylglycerol lipids as a template, we generated a homology model of α3 GlyR-TM structure (Fig. 8 A).

• They have products with CBD per serving as low as 10 mg to bottle with 1500 mg of CBD oils at your disposal.
• Sciatica generally causes both neuropathic and nociceptive pain, and research indicates that CBD can alleviate both types.
• Numerous animal studies, CBD oil has been found to not only prevent brain atrophy, but actually promote neurogenesis, or the regrowth of brain cells.
• High quality CBD products come from companies with good indicators of safety, quality, and transparency.
• Both of these conditions can make physical activity more risky and require extra caution.

There are even receptors in your sensory nerves, these are the nerves that send sensations to your brain so it would appear your endocannabinoid system may have a role to play in moderating pain. Cannabinoids also regulate the expression of the T-box transcription factor, Tbr, which may be central in mediating the neurogenic effects of cannabinoids. Interestingly, this indicates that prenatal exposure to WIN-55,212-2 impacts the differentiation of glutamatergic neurons in the developing cerebral cortex.

Sublingual CBD: Everything You Need To Know

One dropper, containing approximately 33mg of CBD in a 1000mg bottle, twice a day, should be a great place to start. The sciatic nerve is embedded in the lower back and moves down through each leg. Women’s Health participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites.

• The last thing you want to do is spend money on a CBD product that doesn’t contain any CBD or that is full of dangerous substances.
• CBD can also affect ion channel receptors, such as vanilloid type 1 receptors.
• It commonly affects the hands and feet, but can also interfere with automatic functions, such as digestion.
• CBD may also reduce how many immune cells build up in the spinal column, which can reduce inflammation and pain as well.
• All three are known to reduce pain and inflammation and promote relaxation.
• There are four main divisions of the spinal cord — organized according to the vertebral column.

The rash can also be treated with essential oils from plants such as tea tree, chamomile, and eucalyptus. You can choose from two types of CBD — full-spectrum oil and capsules — which isn’t the broadest product selection out there, but it definitely beats many companies with the quality of the formula. This nerve damage results in loss of voluntary and involuntary motor control. Some neurologists have compared degenerative myelopathy in dogs to Multiple Sclerosis in humans. But new research shows it’s closer to ALS … or Lou Gehrig’s Disease. In degenerative myelopathy your dog’s own immune system attacks the myelin sheath.

HemopressinOligodendroglial differentiation within SVZ NPC/NSC culturesIncreasedXapelli et al. Finally, several hormones including thyroid hormones (Remaud et al., 2014), glucocorticoids and, perhaps more speculatively, oxytocin have been linked to neurogenesis regulation. Receptor activation rate for current induced by 1 mM glycine was Oursons au CBD végan estimated by measuring the slope of the initial inward component of current between 10 and 90% of the maximal current (10–90% rise time). Receptor desensitization was induced by 1 mM glycine for 10 s in cells voltage-clamped at −60 mV. The deactivation time was recorded for 30 s immediately after 10 ms application of 1 mM glycine.

Just like every good thing comes with its own set of cons, CBD oil for neuropathy treatment is no exception. It certainly takes a toll on your health if you do not use the oil in the right proportion. So here are the most vital side effects that y.ou must know of. CBD oil for Neuropathy has proven to help people suffering from it. Cannabinoids ought to reduce the pain by making modifications to these cellular events. They also put a stop to the nociceptive conduction that happens in the dorsal horn around the spinal cord.

CBD & Medical Cannabis On The Isle Of Man

This is why conditions that affect the circulatory system are also conditions that can cause nerve damage. While painful symptoms of peripheral neuropathy might make it seem like exercise is not a good idea, this couldn’t be further from the truth. CBD has been validated as an anti-inflammatory agent in several studies—it also has neuroprotective properties. They often know that in clinical trials, they may be randomized into the “placebo” group, and may not want to deal with a potentially worse situation.

• Try to purchase from brands that post COAs for each batch of CBD oil products they produce.
• The content of this article is not intended to be a substitute for professional medical advice, examination, diagnosis, or treatment.
• Did you know that CBD oil is a natural and safe method of treating nerve pain?
• It can sometimes fade when left alone, but the condition can also be chronic.

In fact, hemp-derived CBD oil must have 0.3 percent or less THC content as mandated by law. If a nerve is pinched for just a short duration, there’s generally no long-standing damage. After the pressure is relieved, nerve function gets back to normal.

This is why a lot of people eventually choose to look elsewhere for help managing nerve damage pain, and a lot of the time that is CBD oil. Nerve pain is also referred to as neuropathy or peripheral neuropathy, which is defined as “any condition that affects the normal activity of the nerves of the peripheral does cbd help with halitosis nervous system,”. A condition that occurs when the nerve damage is so extreme the neurotransmitters send confused or exaggerated messages to the brain from the skin, keeping the pain around much longer than the rash. It can appear without any apparent cause and can affect practically any part of the body.

Tried And True: Celebrating National CBD Day

These nerves send sensation to the brain, so it appears that the endocannabinoid system has a role in moderating pain. The primary reason people shift to CBD products with CBD oil for neuropathic pain is its ability to reduce the dependability of pain medication. As mentioned before, CBD can help suppress nerve pain since it potentiates your glycine receptors. If you didn’t know your glycine receptors are very important as they have a big role when it comes to the synaptic inhibition of your brainstem and spinal cords.

• As you will know if you or someone close to you suffers from glaucoma, high eye pressure is a primary risk factor for people with the disease.
• There are also two separate types of neuropathic pain to be aware of.
• All of these potential effects existing in one compound is an exciting prospect for researchers and patients alike.
• Before purchasing your CBD oils, make sure that you get precisely what you are looking for.
• Although Gold Bee doesn’t have any CBD topicals in its line up , you can choose from full-spectrum softgels and broad-spectrum vegan gummies if CBD oil isn’t your pair of shoes.

As mentioned above, someone on our team experiences sciatica pain. This tester found that these two products were very effective in treating her sciatic nerve pain, especially together. She found that taking the Spruce CBD oil on a schedule twice a day and then using the topical as needed for acute symptoms was the best plan for her—but it could be different for others. Medical marijuana has been touted to generally ease physical and emotional pain, including nausea related to cancer treatment, chronic pain, general anxiety disorder, and other conditions. In the 1970s and 1980s, medical marijuana was studied as an eye treatment, particularly for serious conditions like cataracts and glaucoma, which can lead to blindness.

Cbd Dosage For Neuropathy

We’ll talk about what sciatica is, who gets it, how it feels, and how CBD can work to treat it. We’ll explain why we like Spruce CBD generally and why we like Spruce CBD oil and Spruce CBD salve as complementary therapy for sciatica. The best way to use CBD for glaucoma is in a true full-spectrum product that has a cannabinoid profile as close does cbd oil help neuropathy pain in feet to the raw plant as possible. A delta 8 THC oil or tincture is another good option to consider. Both cannabinoids have their place in treating the disease, but like any medication, there are some downsides. If you can deal with the psychoactive effects of full-spectrum THC-containing cannabis oil, it will benefit the disease massively.

• This is why CBD creams, lotions, and salves tend to be more preferred by those suffering from localized nerve or muscle pain like arthritis, neuropathy, etc.
• The entourage effect is still produced by broad-spectrum CBD to some extent, but broad-spectrum products lack the trace amounts of THC that full-spectrum extracts retain.
• Another study shows that the potentiation of your glycine receptors can lead to cannabis-induced analgesia which opens up the therapeutic effects of the cannabis plant especially when it comes to the nerves.
• Reviewers appreciate the quality they get with CBDistillery products and love that this oil brings quick relief.

Some reports suggest that CBD may possess anti-anxiety and anti-emetic characteristics. CBD inhibits inflammation and neuropathic pain as per the reports in the Journal of Experimental Medicine. Royal CBD might be a little expensive when compared to other CBD products but they use the amazing CO2 extraction method and medically review their products via third-party labs. The data that they use seem authentic and a lot of people have claimed that they have the best CBD oils that help deal with neuropathic pain and peripheral neuropathy. Spruce CBD is one of the most recommended CBD products and brands for your nerves, nerve damage, chronic pain, and neuropathic pain. Their CBD products are potent with their most potent product having a concentration of up to 2400 mg of CBD per bottle.

A recent scientific study report a 66% drop in diabetes-related peripheral neuropathy pain in patients who got their feet massaged with essential oils, compared to a 9% drop only for others. Besides CBD oil, Zatural Hot Cream contains over 20 plant extracts and essential oils with valuable benefits for neuropathy pain and symptoms. Helichrysum flower oil is believed to does cbd oil help herniated disc pain help regenerate nerves and connective tissues, while Basil is known as a good nerve tonic. There’s also Peppermint oil to help boost blood circulation and reduce swelling, and Chamomille for its incredible soothing properties. Contains all the compounds found naturally in the cannabis plant — including THC (but never more than 0.3 percent if it’s federally legal).

On the other hand, with 900 mg of CBD per ounce, it’s also the one with the highest actual CBD concentration. The CBD pain cream market is saturated and full of creams and balms that contain little to zero CBD of low quality. Most of CBD’s side effects come from excessive dosage and include dry mouth, diarrhea, reduced appetite, drowsiness, fatigue, or damage to the liver in rare cases. It’s much cheaper than pharmaceutical painkillers and has very few side effects. Following the legalization of CBD at the federal level in 2018, products derived from CBD have literally mushroomed. You can find CBD foods, drinks, gummies, CBD beauty products, CBD for pets, CBD-infused clothing, and pretty much CBD-everything.

Above all, CBD oil is a better option than pharmaceutical painkillers due to its lack of side effects, and it does not pose the risk of developing an addiction. In the United States today, approximately20 million peoplesuffer from some form of nerve damage, and it’s especiallycommonfor those with diabetes, HIV, and on cancer treatment. Both the THC and CBD found in cannabis have been shown to help positively regulatesensory,motor, andautonomicnerve responses in people with a wide variety of debilitating conditions.

Most of the legality of CBD oil in the United States revolves around which plant is used in the manufacturing of CBD oil. Currently, in most of the United States, the legal status of CBD oil is constantly changing. While all 50 states have different levels of restriction, the federal government still has boutiquetoyou.com CBD oil in the same illegal category as marijuana, but they don’t often enforce it. If the patient has a low sensory response or no response at all to the pinprick, then they might be suffering from neuropathic pain. Let’s take a look at a few reasons why you might be suffering from neuropathic pain.

Generally, this procedure does take some time, as it is essentially “retraining” the body to return to a normal range of function. Another minor surgery is a nerve release, which can help to fix nerve compression seen in nerve damage like carpal tunnel syndrome. Minor surgery can be an arthroscopic surgery to unblock the pinched nerve or sew the damaged ends of the nerves together. These tests may find the location of the nerve damage and its severity.

• Cannabidiol and delta-9-tetrahydrocannabinol are two of the several types of cannabinoids found in marijuana.
• This broad-spectrum product is ideal for anyone that travels or wants a discrete solution for nerve pain.
• Neuropathic pain can feel like tingling, numbness, and more severe cases, shooting, and burning pain.
• Even so, it already seems obvious that this cannabinoid has remarkable pain-relieving and anti-inflammatory properties.

Overall, Receptra Naturals is a wonderful brand that has a lot going on it. Sign up today and receive special promotions and offers on Great CBD products while staying up to date on the latest CBD news. A 2018 review of studies suggested that CBD may reduce depression and anxiety related to stress. By interacting with the ECS, CBD may affect how your brain receptors respond to serotonin and inhibit the reuptake of the ‘joy’ hormone, anandamide.

However, note that the formula isn’t all-natural and this cream does contain some chemicals. It may not be a problem for you but if you’re looking for clean, organic, all-natural compositions, this is not your best choice. It’s one of the rare CBD oils formulated for topical use and not for oral consumption. The result is quite efficient as this serum penetrates the tissues and enters the bloodstream within 10 minutes after application.

• Unfortunately there are lots of low grade products out there that may have some CBD but have precious little else in them and so they are either a complete waste of money or do not work very well at all.
• The recent cannabis reforms have put into focus the many pain-relieving qualities of cannabis Sativa.
• All unopened products can be returned within 30 days for a full refund.
• That may not be a gold standard approach in modern medicine, but people have been using this approach for thousands of years.
• The results concluded that CBD was in fact mildly effective in reducing pain.
• This is because without the relief it gets from intermittent movement, the spine is under pressure for too long just from being held still.

And according to some small, preliminary human trials, there’s a chance CBD may also help alleviate neuropathic pain . While inflammation itself is necessary for your survival, an overactive inflammatory response isn’t does cbd oil help with seizures good.Neuroinflammation plays a role in many neurological conditions. Research has linked inflammation to a range of issues from depression, anxiety, Alzheimer’s disease, and memory trouble to stroke and epilepsy.

The rash itself is quite painful and consists of reddened skin covered with fluid-filled blisters along a single band or stripe somewhere on the body. Neuropathic or nerve pain tends to feel like a burning or prickling—a sense of “pins and needles.” Often, people with neuropathic pain may be hypersensitive to movement, temperature, and touch. Neuropathic pain is caused by damage to the nerves that transmit the signal from the injured area to the brain. Neuropathic pain can also be caused by injury, inflammation, lack of oxygen and/or a specific disease, but it can also be caused by medication or a stroke, or even infections like HIV or bacterial infections. Everyone is different which means that CBD works differently for each person. Nerve pain can be very painful at times, affecting not only the nerves but also other areas of the body.

I wake up in the middle of the night with this feeling of electricity shooting down my legs. On the other hand, CBD edibles, tinctures, and vapes have to get into the bloodstream for you to experience CBD’s benefits. When applied directly to the affected area, CBD topicals help concentrate all the benefits of CBD to the target area. This cannabis-derivative has equal parts of THC and CBD and has been found to help with neuropathy. The peripheral nervous system helps send information from your central nervous system to the rest of the body. The system also relays sensory information to your central nervous system.

CBD Oil In Maine: Is It Legal & Where To Buy In 2022?

Users have provided positive reviews relating to the product’s ability to help relieve muscular pain. Please note that the writer of this article has not tried these products. For more information and resources on CBD and CBD products, please visit our dedicated hub. Chane Leigh, aka The Bud Fairy, is a South African cannabis advocate and enthusiast with a firey personality and a thirst for travel.

• Some people experience a dull pain, others almost a burning sensation and others severe pain.
• For instance, the role of spinal CB1 receptors in the pain process is debatable.
• As your muscles lose their ability to properly contract, they can start to waste away.
• When it comes to finding a good CBD oil company to help with nerve pain, it’s going to be hard to beat Verma Farms.
• Nerve damage can occur because of autoimmune diseases, motor neuron diseases, cancer, infection, or diabetes.

No matter what’s causing neuropathic pain, the benefits of CBD remain much the same. Nerves leave the brain and head down the spinal cord in bundles and pairs. They branch off at various points along the way to go to their target organs, and some tracts will cross sides. Spinal cord injuries can have debilitating and life-altering consequences. Injuries can cause varying levels of paralysis, spasticity, loss of sensation, muscle weakness, and nerve pain that can persist for the rest of that person’s life.

When administered at the first sign of tremors, cannabinoids were found to delay motor impairment and prolong survival. As it stands, treatments for neurodegenerative conditions leave a lot to be desired. At best, they slow the progression of the disease but can cause undesirable side effects; at worst, they do nothing much at all. As more studies are being conducted in this area, CBD may become the go-to treatment option for neuropathy in the future. However, CBD isn’t the only cannabinoid found in cannabis that can help alleviate neuropathy.

There is really nothing to lose by giving it a try and seeing if it helps you with your sciatica or numerous other ailments. CBD can be applied topically, ingested, or even vaporized to reap its potential benefits. It is extracted from hemp oil and is now legal in all 50 states. It is a natural Helfen CBD Gummibärchen bei Schmerzen? compound found in hemp, marijuana, and all strains of cannabis. This cannabinoid has been found to provide effective relief for all sorts of disorders, but especially inflammation, pain, and seizures. If you are not concerned, it may be the medications themselves making you apathetic.

• Reap all of the benefits of cannabis plant without any potentially intoxicating effects.
• To make sure this does not happen, you can seek physiotherapy or hand therapy to maintain the feeling and action of movement while the nerves regenerate.
• This is one of the ways that CBD oil is thought to help with pain, hormonal imbalance symptoms, mood imbalance symptoms, etc.
• Although there are various types of medications that can be prescribed to patients who suffer from nerve pain, many people prefer natural remedies like CBD oil.

Like diabetes, Multiple Sclerosis , shingles, or any injury sustained to the spinal cord or brain. We’ll answer those questions and more in this guide to medical marijuana and neuropathic pain. Alternative treatments for pain management, such as CBD oil for nerve pain, are being explored for many reasons.

• As its popularity rises, the anecdotal reports continue to flood the internet and research is ongoing.
• However, there’s currently not enough clinical evidence to confirm this hypothesis.
• Aspen Green is probably one of the best choices in this list when it comes to price and value.
• One 2016 study examining the application of a CBD gel onto rat skin concluded that it can reduce inflammation and pain.
• One group of researchers pooled together data from 5 different studies on the impact of CBD on neuropathic pain in 41 patients.

Since you don’t have complete control over the muscles, it’s possible that you might develop abnormal postures. To make sure this does not happen, you can seek physiotherapy or hand therapy to maintain the feeling and action of movement while the nerves regenerate. There are still relatively few human studies available—and even fewer studies using CBD alone. Most of the studies use cannabis-derived combinations of THC (tetrahydrocannabinol, the cannabinoid which produces a “high”), CBD, and synthetic cannabinoids. Topical CBD was able to reduce inflammation and pain caused by arthritis, a recent study reported. Referred pain, or reflective pain, is described as pain felt in a location other than where the actual damage is.

Whether you’re sitting at a desk for eight hours at a time or engaging in repetitive motions, sciatic nerve pain is more likely to develop in people who work these types of jobs. When protective discs that offer padding between the spinal cord and bones start to break down, it can cause discomfort and pain from pressure on the sciatic nerve. This is called degenerative disc disease, and it is another cause of sciatica. Most medical research suggests that CBD does not intoxicate you the same way THC does, but taking types of medical marijuana marketed as “high CBD” might mean there are traces of THC included in the substance. THC is addictive because it can change brain chemistry to make you feel relaxed, less anxious, sleepy, or even happy.

The recommended strain of marijuana is one that has been proven to offer significant pain relief. As mentioned earlier, CBD works perfectly even when you take it in small quantities. Taking too much of anything, including CBD oils will most likely land you in trouble. does cbd oil help cancer Some states have not fully legalized the use of marijuana or any of its products. Be sure you are on the right side of your state’s law before you start using CBD. Cannabinoids found in cannabis can fix this problem and enable you to live a fulfilling life.

A cancer patient after chemotherapy, HIV, or people in their 50s and older — especially those under severe stress — are more likely to get shingles. If you take medicines that weaken the immune system , you’re in the group of higher risk, too. You just need to ensure that the skin stays clean, dry, and free of other substances that could compromise the efficacy of the topical. When it comes to topicals, we suggest that you apply them to the affected area once daily or as recommended by your physician. Doing so can help ease the pain and reduce itchiness that accompanies shingles. The hemp should come from a licensed producer and be processed by a reputable brand.

• In contrast, CBD oil has proven to have anticonvulsant and antidepressant benefits in addition to its anti-inflammatory properties.
• At the end of the day, our goal is to make it easier for you to find high-quality CBD oils that work effectively in relieving nerve pain.
• It is essential to understand that oral CBD oil products can take up to 40 minutes to work, depending on what you have eaten for the day.
• LupusCorner, a website for patients with the condition run by health-care technology developer Progentec Diagnostics, conducted an online survey in 2016 asking readers about cannabis use.
• These products are gently extracted using supercritical CO2 to preserve the original cannabinoid profile of the hemp plant without using additional heat or solvents.
• You are advised to seek further medical attention if the side effects become a nuisance.

Most manufacturers suggest that beginners start with a small dose and increase over time. This way, you can get a feel for how the product works with your body and affects your symptoms. However, there’s no official recommended dose for any CBD product. For all of CBD’s known benefits, it’s unclear how much CBD can do for nerve pain.